The Benefits of Nanoparticles predicted efficacy in treating blood cancers
Previously, a study says nanoparticles can be a method to cure cancer. It is now proven by a new study from the University of Notre Dame have demonstrated the effectiveness of nanoparticles in treating multiple myeloma (MM), a blood cancer that attacks the plasma cells in the spinal cord.
During this refractory MM is because these types of cancer cells began to resistant to chemotherapy.
"Nanoparticles that we developed showed beneficial results. Firstly, the nanoparticles lower the cancer defense reaction against doxorubicin treatment. Secondly, this method makes the cancer cells take nanoparticle drugs. Thirdly, the toxic effects of the drug on healthy organs also revealed," he said Baar Bilgier one researcher, as quoted by Science Daily (18/06).
In the experiment, the nanoparticles protected by a special peptide that targets receptors on MM cells. These receptors causes the spinal cord tissue refuse any drugs, but the use of peptides attached to nanoparticles prevents cancer cells in the bone marrow.
The nanoparticles also carry medication with them. When a particle is attached to the MM cells, the tissue will absorb the particles so that the drug will be launched and make cancer DNA is damaged and die.
"Our studies in mice showed nanoparticles formula reduces the toxic effects of cancer drugs on healthy tissues, such as kidney and liver," said another researcher, Tanyel Kiziltepe.
Before developing the research to humans, the research team plans to develop a study to improve the design of nanoparticles and found the number and the maximum combination of chemotherapy drugs.
During this refractory MM is because these types of cancer cells began to resistant to chemotherapy.
"Nanoparticles that we developed showed beneficial results. Firstly, the nanoparticles lower the cancer defense reaction against doxorubicin treatment. Secondly, this method makes the cancer cells take nanoparticle drugs. Thirdly, the toxic effects of the drug on healthy organs also revealed," he said Baar Bilgier one researcher, as quoted by Science Daily (18/06).
In the experiment, the nanoparticles protected by a special peptide that targets receptors on MM cells. These receptors causes the spinal cord tissue refuse any drugs, but the use of peptides attached to nanoparticles prevents cancer cells in the bone marrow.
The nanoparticles also carry medication with them. When a particle is attached to the MM cells, the tissue will absorb the particles so that the drug will be launched and make cancer DNA is damaged and die.
"Our studies in mice showed nanoparticles formula reduces the toxic effects of cancer drugs on healthy tissues, such as kidney and liver," said another researcher, Tanyel Kiziltepe.
Before developing the research to humans, the research team plans to develop a study to improve the design of nanoparticles and found the number and the maximum combination of chemotherapy drugs.
Nanoparticles predicted efficacy in treating blood cancers
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